Langeveld JPM, Erkens JHF, Rammel I, Jacobs JG, Davidse A, van Zijderveld F, Bossers A, and Schildorfer H.
Four independent molecular prion protein parameters for discriminating new cases of C, L, and H BSE in cattle. J. Clin. Microbiol. 49: 3026-3028. Project BAS nr: WOT-01-002-001.01.
Kuczius T, Brandstädter L, Karch H, Langeveld JPM. 2011. A duplex approach for immunochemical staining and typing of protein in western blots. Anal. Biochem. 409: 260-266
Jacobs JG, Sauer M, van Keulen LJM, Tang Y, Bossers A, and Langeveld JPM. 2011. Differentiation of ruminant TSE isolate types, including BSE and CH1641 scrapie. J. Gen. Virol. 92: 222-232
Alan Rigter, Jan P.M. Langeveld, Fred G. van Zijderveld and Alex Bossers. 2010. Prion Protein Self Interactions; a gateway to novel therapeutic strategies? Vaccine 28: 7810-7823.
Hoffmann C, Eiden M, Kaatz M, Keller M, Ziegler U, Rogers R, Hills B, Balkema-Buschmann A, van Keulen L, Jacobs JG, Groschup MH. BSE infectivity in jejunum, ileum and ileocaecal junction of incubating cattle. Vet. Res. 42: 21. Project BAS nr: WOT-01-002-001.01.
Polak MP, Larska M, Langeveld JPM, Buschmann A, Groschup MH, Zmudzinski JF. (2010). Diagnosis of the first cases of scrapie, an atypical variant, in Poland. Vet. J. 186: 47-52.
González L., Sisó S., Monleón E., Casalone C., van Keulen LJM., Balkema-Buschmann A., Ortiz-Peláez A., Iulini B., Langeveld JPM., Hoffmann C., Badiola.JJ., Jeffrey M., and Acín C. (2010) Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe. J. Gen. Virol. 91: 2630-2641.
Bouzalas I, Lörtscher F, Dovas C, Oevermann A, Langeveld JPM, Papanastassopoulou M, Papadopoulos O, Zurbriggen A, and Seuberlich A distinct proteinase K resistant prion protein fragment in goats with no signs of disease in a classical scrapie outbreak . J. Clin. Microbiol. 49: 2109-2115. Project BAS nr: WOT-01-002-001.01
Hicham Filali, Inmaculada Martin-Burriel, Frank Harders, Luis Varona, Jaber Lyahyai, Pilar Zaragoza, Martí Pumarola, Juan J Badiola, Alex Bossers, Rosa Bolea. Gene expression profiling and association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals. PLosOne 6(5): e19909. doi:10.1371/journal.pone. 0019909. Project BAS nr: WOT-01-002-001.01
Pirisinu, L., Di Bari M, Marcon S, Vaccari G, D’Agostino C, Fazzi P, Esposito E, Cardone F, Langeveld J, Agrimi U, Nonno R. (2010) A New Method for the Characterization of Strain-Specific Conformational Stability of Protease-Sensitive and Protease-Resistant PrPSc. PLoS ONE 5 (9): e12723.
Zou W-Q, Puoti G, Xiao X, Yuan J, Qing, L., Cali I, Shimoji M, Langeveld JPM, Castellani R, Notari S, Crain, B., , Schmidt RE, Geschwind M, DeArmond SJ, Cairns N, Dickson, D, Honig L, Torres, JM, Mastrianni, J, Capellari S, Giaccone G, Belay ED, Schonberger LB, Cohen, M, Perry, G, Kong Q, Parchi P, Tagliavini F, Gambetti P. (2010). Protease-Sensitive Prionopathy: A New Sporadic Disease of the Prion Protein. Ann. Neurol. 68: 162-172.
Marielle B Melchior, Jack J Windig, Thomas J Hagenaars, Alex Bossers, Aart Davidse and Fred G Zijderveld van. (2010). Eradication of scrapie with selective breeding: are we nearly there?. BMC Vet. Res. 6: 24.
Dobly A, Langeveld J, Rodeghiero C, Durand S, Geeroms R, vanMuylem P, de Sloovere J, Vanopdenbosch E, Roels S. (2010)No H- and L-type cases in Belgium in cattle diagnosed with bovine spongiform encephalopathy (1999-2008) aging seven years and older. BMC Vet. Res. 6:26; doi:10.1186/1746-6148-6-26.
Thomas J. Hagenaars, Marielle B. Melchior, Alex Bossers, Aart Davidse, Fred G. van Zijderveld. (2010). Scrapie incidence in sheep of susceptible genotype is declining in a population subject to breeding for resistance. BMC Vet. Res. 6: 25.
Zou, W-Q, Langeveld J, Xiao X., Chen S, McGeer PL, Yuan J, Payne MC, Kang H-E, McGeehan JM, Sy M-S,Greenspan NS, Kaplan D, Wang G-X, Parchi P, Hoover E, Kneale G, Telling G, Surewicz W, Kong Q, Guo J-P. (2010). PrP conformational translations alter species-preference of a PrP specific antibody. J. Biol. Chem. 285: 13874-13884.
Yue Tang, Jemma Thorne, Kirsty Whatling, Jorg Jacobs, Jan Langeveld and Maurice Sauer. (2010). A single step multiplex immunofluorometric assay for differential diagnosis of BSE and scrapie. J. Immunol. Meth. 356:29–38.
Christina D. Orru, Jason M. Wilham, Andrew G. Hughson, Lynne D. Raymond, Kristin L. McNally,
Alex Bossers, Ciriaco Ligios and Byron Caughey. Human variant Creutzfeldt–Jakob disease and sheep scrapie PrPres detection using seeded conversion of recombinant prion protein. Protein Engineering, Design & Selection vol. 22 no. 8 pp. 515–521, 2009
Rigter A, Priem J, Timmers-Parohi D, Langeveld JP, van Zijderveld FG, Bossers A. Prion protein self-peptides modulate prion interactions and conversion. BMC Biochem. 2009 Nov 30;10:29
Cali I, Castellani R, Alshekhlee A, Cohen Y, Blevins J, Yuan J, Langeveld JP, Parchi P, Safar JG, Zou WQ, Gambetti P. Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics. Brain. 2009 Oct;132(Pt 10):2643-58.
Parchi P, Strammiello R, Notari S, Giese A, Langeveld JP, Ladogana A, Zerr I, Roncaroli F, Cras P, Ghetti B, Pocchiari M, Kretzschmar H, Capellari S. Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification. Acta Neuropathol. 2009 Nov;118(5):659-71
Polak MP, Larska M, Langeveld JP, Buschmann A, Groschup MH, Zmudzinski JF. Diagnosis of the first cases of scrapie in Poland. Vet J. 2009 Aug 26.
Rigter A, Priem J, Timmers-Parohi D, Langeveld JP, Bossers A. Mapping functional prion-prion protein interaction sites using prion protein based peptide-arrays. Methods Mol Biol. 2009;570:257-71.
Gabriele Vaccari, Cynthia H. Panagiotidis, Cristina Acin, Simone Peletto, Francis Barillet, Pierluigi Acutis, Alex Bossers, Jan Langeveld,Lucien van Keulen, Theodoros Sklaviadis, Juan J. Badiola, Olivier Andréoletti, Martin H. Groschup, Umberto Agrimi, James Foster, Wilfred Goldmann. State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology. Vet. Res. (2009) 40:48
Acutis PL, Colussi S, Santagada G, Laurenza C, Maniaci MG, Riina MV, Peletto S, Goldmann W, Bossers A, Caramelli M, Cristoferi I, Maione S, Sacchi P, Rasero R (2008). Genetic variability of the PRNP gene in goat breeds from Northern and Southern Italy. J Appl Microbiol. 104(6):1782-9
Brandel JP, Heath CA, Head MW, Levavasseur E, Knight R, Laplanche JL, Langeveld JP, Ironside JW, Hauw JJ, Mackenzie J, Alpérovitch A, Will RG, Haïk S. Variant Creutzfeldt-Jakob disease in France and the United Kingdom: Evidence for the same agent strain. Ann Neurol. 2009 Mar;65(3):249-56.
van Keulen LJ, Bossers A, van Zijderveld F. (2008). TSE pathogenesis in cattle and sheep. Vet Res. 39(4):24.
van Keulen LJ, Vromans ME, Dolstra CH, Bossers A, van Zijderveld FG (2008). Pathogenesis of bovine spongiform encephalopathy in sheep. Arch Virol. 153(3):445-53.
Canello, T.; Engelstein, R.; Moshel, O.; Xanthopoulos, K.; Langeveld, J.P.M.; Sklaviadis, T.; Gasset, M.; Gabizon, R. (2008). Methionine Sulfoxides on PrPSc: A Prion-Specific Covalent Signature. Biochemistry 47 (34). - p. 8866 - 8873.
Gavier-Widen, D.; Noremark, M.; Langeveld, J.P.M.; Stack, M.; Biacabe, A.G.; Vulin, J.; Chaplin, M.; Richt, J.A.; Jacobs, J.G.; Acin, C.; Monleón, E.; Renström, A.; Klingeborn, B.; Baron, T.G.M. (2008). Bovine spongiform encephalopathy in Sweden: an H-type variant. Journal of Veterinary Diagnostic Investigation 20 (1). - p. 2 - 10.
Notari, S.; Strammiello, R.; Capellari, S.; Giese, A.; Cescatti, M.; Grassi, J.; Ghetti, B.; Langeveld, J.P.M.; Zou, W.Q.; Gambetti, P.; Kretzschmar, H.A.; Parchi, P. (2008). Characterization of Truncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease. Journal of Biological Chemistry 283 (45). - p. 30557 - 30565.
Polak, M.P.; Zmudzinski, J.F.; Jacobs, J.G.; Langeveld, J.P.M. (2008). Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study. Archives of Virology 153 (1). - p. 69 - 79.
Uro-Coste, E.; Cassard, H.; Simon, S.; Lugan, S.; Bilheude, J.M.; Perret-Liaudet, A.; Ironside, J.E.; Haik, S.; Basset-Leobon, C.; Lacroux, C.; Peoch, K.; Streichenberger, N.; Langeveld, J.P.M.; Head, M.W.; Grassi, J.; Hauw, J.J.; Schelcher, F.; Delisle, M.B.; Andreoletti, O. (2008). Beyond PrPres type 1/Type 2 dichotomy in Creutzfeldt-Jakob disease. PLoS Pathogens 4 (3). - p. e1000029.
Haïk S, Peyrin JM, Lins L, Rosseneu MY, Brasseur R, Langeveld JP, Tagliavini F, Deslys JP, Lasmézas C, Dormont D. Neurotoxicity of the putative transmembrane domain of the prion protein. Neurobiol Dis. 2000 Dec;7
Biacabe, A.G.; Jacobs, J.G.; Bencsik, A.; Langeveld, J.P.M.; Baron, T.G.M. (2007). H-type bovine spongiform encephalopathy-complex molecular featrues and similarities with some human prion diseases. Prion 1 (1). - p. 61 - 68.
Espinosa, J.C.; Andreoletti, O.; Castilla, J.; Herva, M.E.; Morales, M.; Alamillo, E.; San-Segundo, F.D.; Lacroux, C.; Lugan, S.; Salguero, F.J.; Langeveld, J.P.M.; Torres, J.M. (2007). Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice. Journal of Virology 81 (2). - p. 835 - 843.
Jacobs, J.G.; Langeveld, J.P.M.; Biacabe, A.G.; Acutis, P.L.; Polak, M.P.; Gavier-Widen, D.; Buschmann, A.; Caramelli, M.; Casalone, C.; Mazza, M.; Groschup, M.; Erkens, J.H.F.; Davidse, A.; Zijderveld, F.G. van; Baron, T. (2007). Molecular discrimination of atypical bovine spongiform encephalopathy strains from a geographical region spanning a wide area in Europe. Journal of Clinical Microbiology 45 (6). - p. 1821 - 1829.
Notari, S.; Capellari, S.; Langeveld, J.P.M.; Giese, A.; Strammiello, R.; Gambetti, P.; Kretzschmar, H.A.; Parchi, P. (2007). A refined method for molecular typing reveals that co-occurrence of PrPSc types in Creutzfeldt-Jakob disease is not the rule. Laboratory Investigation 87 (11). - p. 1103 - 1112.
Rigter, A.; Langeveld, J.P.M.; Timmers-Parohi, D.; Jacobs, J.G.; Moonen, P.L.J.M.; Bossers, A. (2007). Mapping of possible prion protein self interaction domains using peptide arrays. Biochemistry 8 . - p. 6.
Meade-White K, Race B, Trifilo M, Bossers A, Favara C, Lacasse R, Miller M, Williams E, Oldstone M, Race R, Chesebro B. Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein. J Virol. 2007 May;81(9):4533-9.
Lima, A.B.C., A. Bossers, C.E.A. Souza, S.M.P. Oliveira, S.L.T. Santiago and D.M. Oliveira. (2007). PrP genotypes in a pedigree flock of Santa Inês sheep. Veterinary Record 160:336-337.
Baron, T.G.M.; Biacabe, A.G.; Bencsik, A.; Langeveld, J.P.M. (2006). Transmission of new bovine prion to mice. Emerging Infectious Diseases 12 (7). - p. 1125 - 1128.
Biswas, S.; Langeveld, J.P.M.; Tipper, D.; Lu, S. (2006). Intracellular accumulation of a 46 kDa species of mouse prion protein as a result of loss of glycosylation in cultured mammalian cells. Biochemical and Biophysical Research Communications 349 (1). - p. 153 - 161.
Gretzschel, A.; Buschmann, A.; Langeveld, J.P.M.; Groschup, M.H. (2006). Immunological characterization of abnormal prion protein from atypical scrapie cases in sheep using a panel of monoclonal antibodies. Journal of General Virology 87 . - p. 3715 - 3722.
Jeffrey, M.; Martin, S.; Gonzalez, L.; Foster, J.; Langeveld, J.P.M.; Zijderveld, F.G. van; Grassi, J.; Hunter, N. (2006). Immunohistochemical features of Prp(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies. Journal of Comparative Pathology 134 (2-3). - p. 171 - 181.
Langeveld, J.P.M.; Jacobs, J.G.; Erkens, J.H.F.; Bossers, A.; Zijderveld, F.G. van; Keulen, L.J.M. van (2006). Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep. BMC Veterinary Research 2 (19).
Hunter, N., and Bossers, A. (2006). The PrP genotype as a marker for scrapie susceptibility in sheep. In: PRIONS in humans and animals. Eds: Hörnlimann, Riesner and Kretzschmar. Berlin. p640-647.
Raymond, G.J.; Olsen, E.A.; Lee, K.S.; Raymond, L.D.; Bryant, P.K.; Baron, G.S.; Caughey, W.S.; Kocisko, D.A.; McHolland, L.E.; Favara, C.; Langeveld, J.P.M.; Zijderveld, F.G. van; Mayer, R.T.; Miller, M.W.; Williams, E.S.; Caughey, B. (2006). Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. Journal of Virology 80 (2). - p. 596 - 604.
Yull, H.M.; Ritchie, D.L.; Langeveld, J.P.M.; Zijderveld, F.G. van; Bruce, M.E.; Ironside, J.W.; Head, M.W. (2006). Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease. American Journal of Pathology 168 (1). - p. 151 - 157.
Acutis PL, A. Bossers, J. Priem, M.V. Riina, S. Peletto, M. Mazza, C. Casalone, G. Forloni, G. Ru, M. Caramelli (2006). Identification of prion protein gene polymorphisms in goats from Italian scrapie outbreaks. Journal of General Virology 87:1029-23.
Sharpe, A.; McElroy, M.; Langeveld, J.P.M.; Bassett, H.; O'Donoghue, A.M.; Sweeney, T. (2005). Immunohistochemical studies of scrapie archival material from Irish ARQ/ARQ sheep for evidence of bovine spongiform encephalopathy-derived disease. Research in Veterinary Science 79 (1). - p. 29 - 35.
Rigter, Alan and Alex Bossers (2005). Sheep scrapie susceptibility-linked polymorphisms do not modulate the initial binding of cellular to disease-associated prion protein prior to conversion. J. Gen. Virol. 86:2627-2634.
Thuring, C.M.A.; Keulen, L.J.M. van; Langeveld, J.P.M.; Vromans, M.E.W.; Zijderveld, F.G. van; Sweeney, T. (2005). Immunohistochemical distinction between preclinical bovine spongiform encephalopathy and scrapie infection in sheep. Journal of Comparative Pathology 132 (1). - p. 59- - 69.
Veerhuis, R.; Boshuizen, R.S.; Morbin, M.; Mazzoleni, G.; Hoozemans, J.J.; Langedijk, J.P.; Tagliavini, F.; Langeveld, J.P.M.; Eikelenboom, P. (2005). Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q. Neurobiology of Disease 19 (1-2). - p. 273 - 282.
Acutis P.L., Sbaiz L., Verburg F., Riina.M.V., Ru. G., Moda G., Caramelli M., Bossers A. Low level of the scrapie resistance-associated allele and presence of lysine-171 allele of the prion protein gene in Italian Biellese ovine breed. J. General Virology. June 2004.
Bate, C.; Langeveld, J.P.M.; Williams, A. (2004). Manipulation of PrPres production in scrapie-infected neuroblastoma cells. Journal of Neuroscience Methods 138 (1-2). - p. 217 - 223.
Boshuizen, R.S.; Langeveld, J.P.M.; Salmona, M.; Williams, A.; Meloen, R.H.; Langendijk, J.P. (2004). An in vitro screening assay based on synthetic prion protein peptides for identification of fibril-interfering compounds. Analytical Biochemistry 333 (2). - p. 372 - 380.
Sachsamanoglou, M.; Paspaltzis, I.; Petrakis, S.; Verghese-Nikolakaki, S.; Panagiotidis, C.H.; Voitlander, T.; Budka, H.; Langeveld, J.P.M.; Sklaviadis, T. (2004). Antigenic profile of human recombinant PrP: generation and chracterization of a versatile polyclonal antiserum. Journal of Neuroimmunology 146 (1). - p. 22 - 32.
Thuring, C.M.A.; Erkens, J.H.F.; Jacobs, J.G.; Bossers, A.; Keulen, L.J.M. van; Garssen, G.J.; Zijderveld, F.G. van; Ryder, S.J.; Groschup, M.H.; Sweeney, T.; Langeveld, J.P.M. (2004). Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein. Journal of Clinical Microbiology 42 (3). - p. 972 - 980.
Langeveld, J.P.M.; Wang, J.J.; Wiel, D.F.M. van de; Shih, G.C.; Garssen, G.J.; Bossers, A.; Shih, J.C.H. (2003). Enzymatic degradation of prion protein in brain stem from infected cattle and sheep. Journal of Infectious Diseases 188 (11). - p. 1782 - 1789.
Bossers, A., Rigter, A., de Vries, R., and Smits, M.A. (2003). In vitro conversion of normal PrP to pathological isoforms of PrP. Invited review in: Prion Diseases. Clinics in Laboratory Medicine 23:227-247. Editor. B. Ghetti., Piccardo P., and Schmidt R..
Bate, C.; Boshuizen, R.S.; Langeveld, J.P.M.; Williams, A. (2002). Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation. NeuroReport 13 (13). - p. 1695 - 1700.
Sigurdson, C.J.; Barillas-Mury, C.; Miller, M.W.; Oesch, B.; Keulen, L.J.M. van; Langeveld, J.P.M.; Hoover, E.A. (2002). PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer. Journal of General Virology 83 (10). - p. 2617 - 2628.
Veerhuis, R.; Hoozemans, J.J.M.; Janssen, I.; Boshuizen, R.S.; Langeveld, J.P.M.; Eikelenboom, P. (2002). Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E-2. Brain research 925, 195-203. - ISSN 0006-8993
Garssen, G.J.; Keulen, L.J.M. van; Farquhar, C.F.; Smits, M.A.; Jacobs, J.G.; Bossers, A.; Meloen, R.H.; Langeveld, J.P.M. (2000). Applicability of three anti-PrP peptide sera including staining of tonsils and brainstem of sheep with scrapie. Microscopy research and technique 50, 2000, 32-39
Keulen, L.J.M. van; Langeveld, J.P.M.; Garssen, G.J.; Jacobs, J.G.; Schreuder, B.E.C.; Smits, M.A. (2000). Diagnosis of bovine spongiform encephalopathy: a review. Veterinary quarterly 22, 2000, 197-199
Keulen, L.J. van; Schreuder, B.E.; Vromans, M.E.; Langeveld, J.P.; Smits, M.A. (2000). Pathogenesis of natural scrapie in sheep. Archives of Virology, Supplement, 57-71
Alex Bossers, Ruth de Vries, and Mari A. Smits (2000). Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine natural occurring variants of PrP. Journal of Virology vol 74 no 3 p 1407-1414.
Keulen, L.J.M. van; Schreuder, B.E.C.; Vromans, M.E.W.; Langeveld, J.P.M.; Smits, M.A. (1999). Scrapie-associated prion protein in the gastro-intestinal tract of sheep with natural scrapie. Journal comparative pathology 121, 1999, 55-63
Alex Bossers, Frank L. Harders, and Mari A. Smits. (1999). PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie. Archives of Virology 144:829-834.
Roels, S.; Vanopdenbosch, E.; Langeveld, J.P.M.; Schreuder, B.E.C. (1999). Immunohistochemical evaluation of tonsillar tissue for preclinical screening of scrapie based on surveillance in Belgium. Veterinary record 145, 1999, 524-525
Rubenstein, R.; Kascsak, R.J.; Papini, M.; Kascsak, R.; Carp, R.I.; LaFauci, G.; Meloen, R.; Langeveld, J.P.M. (1999). Immune surveillance and antigen conformation determines humoral immune response to the prion protein immunogen. Journal of neurovirology 5, 1999, 401-413
Lo-Man, R.; Langeveld, J.P.M.; Martineau, P.; Hofnung, M.; Meloen, R.H.; Leclerc, C. (1998). Immunodominance does not result from peptide competition for MHC class II presentation. Journal of immunology 160, 1998, 1759-1766
Piccardo, P.; Langeveld, J.P.M.; Hill, A.F.; Dlouhy, S.R.; Young, K.; Giaccone, G.; Rossi, G.; Bugiani, O.; Meloen, R.H.; Colling, J.; Tagliavini, F. (1998). An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. American journal of pathology 152, 1998, 1415-1420
Schreuder, B.E.C.; Keulen, L.J.M. van; Vromans, M.E.W.; Langeveld, J.P.M.; Smits, M.A. (1998). Tonsillar biopsy and PrPSc detection in the preclinical diagnosis of scrapie. Veterinary record 142, 1998, 564-568
Schreuder, B.E.C.; Keulen, L.J.M. van; Smits, M.A.; Langeveld, J.P.M.; Stegeman, J.A. (1997). Control of srapie eventually possible?. Veterinary quarterly 19, 1997, 105-113
G.J. Raymond, J. Hope, D.A. Kocisko, S.A. Priola, L.D. Raymond, A. Bossers, J. Ironside, R.G. Will, S.G. Chen, R.B. Petersen, P. Gambetti, R. Rubenstein, M.A. Smits, P.T. Lansbury Jr, and B. Caughey. (1997). Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature 388:285-288.
Alex Bossers, Peter B.G.M. Belt, Gregory J. Raymond, Byron Caughey, Ruth de Vries, and Mari A. Smits. (1997). Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms. Proc. Natl. Acad. Sci. USA 94:4931-4936.
M.A. Smits, A. Bossers, and B.E.C. Schreuder. (1997). Prion protein and scrapie susceptibility. Veterinary Quartely 19:101-105.
Alex Bossers, Bram E.C. Schreuder, Ida H. Muileman, Peter B.G.M. Belt, and Mari A. Smits. (1996). PrP genotype contributes to determining survival times of sheep with natural scrapie. Journal of General Virology 77:2669-2673.
Keulen, L.J.M. van; Schreuder, B.E.C.; Meloen, R.H.; Mooij-Harkes, G.; Vromans, M.E.W.; Langeveld, J.P.M. (1996). Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. Journal clinical microbiology 34, 1996, 1228-1231
Schreuder, B.E.C.; Keulen, L.J.M. van; Vromans, M.E.W.; Langeveld, J.P.M.; Smits, M.A. (1996). Preclinical test for prion diseases. Nature 381, 1996, 563
Keulen, L.J.M.; Schreuder, B.E.C.; Meloen, R.H.; Poelen-van der Berg, M.; Mooij-Harkes, G.; Vromans, M.E.W.; Langeveld, J.P.M. (1995). lmmunohistochemical detection and localization of prion protein in brain tissue of sheep with natural scrapie. Veterinary pathology 32, 1995, 299-308